Prairie Girl has a couple cartoons on the matter, and they’re particularly poignant to me, because the ghost town she left is the little city that I’ve made my home.
(Clicking the image will take you to the whole story.)
I grew up in a much smaller town—pop. ~1200—and now it’s home only to my father. I didn’t even attend my 25-year high school reunion last summer (though, to be fair, I had my reasons, which included a scheduling conflict).